Biomedical and environmental sciences : BES · 2009
Attenuation of carbon tetrachloride-induced hepatotoxicity by cow urine distillate in rats.
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Gururaja M P, Joshi A B, Joshi Himanshu, Sathyanarayana D, Subrahmanyam E V S, Chandrashekhar K S
Аннотация
OBJECTIVE: To study the carbon tetrachloride-induced hepatoprotective activity in cow urine.
METHODS: Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride (CCl4). Hepatotoxicity was induced by a 1:1 (v/v) mixture of CCl4 in olive oil (5 mL/kg i.p). Protective effect of cow urine distillate (in three dose levels) and standard drug Silymarin (100 mg/kg, p.o) on liver function were studied in intoxicated rats. Parameters in the study included liver function tests and histological observations.
RESULTS: The cow urine distillate decreased the levels of SGOT, SGPT, ALP, GGT, and total bilirubin in a dose-dependent manner (P < 0.05) as sylimarin.
CONCLUSION: The observed protective effects of cow urine distillate on liver function might be due to the presence of antioxidants in cow urine.
METHODS: Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride (CCl4). Hepatotoxicity was induced by a 1:1 (v/v) mixture of CCl4 in olive oil (5 mL/kg i.p). Protective effect of cow urine distillate (in three dose levels) and standard drug Silymarin (100 mg/kg, p.o) on liver function were studied in intoxicated rats. Parameters in the study included liver function tests and histological observations.
RESULTS: The cow urine distillate decreased the levels of SGOT, SGPT, ALP, GGT, and total bilirubin in a dose-dependent manner (P < 0.05) as sylimarin.
CONCLUSION: The observed protective effects of cow urine distillate on liver function might be due to the presence of antioxidants in cow urine.