Pharmacopsychiatry · 2015
Antidepressant Treatment with Venlafaxine and Mirtazapine: no Effect on Serum Concentration of Vascular Endothelial Growth Factor (VEGF).
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Deuschle M, Gilles M, Scharnholz B, Kahl K G
Аннотация
INTRODUCTION: Depression, stress and antidepressant treatment have been found to modulate the expression of growth factors.
METHODS: We studied depressed patients receiving randomized treatment with venlafaxine or mirtazapine for 28 days.
RESULTS: There was no significant difference between baseline VEGF concentrations in depressed patients compared to healthy controls. We found no significant effect of antidepressant treatment on serum VEGF.
DISCUSSION: In contrast to serum BDNF, VEGF may not be a suitable biomarker for effects of antidepressant treatment with venlafaxine or mirtazapine.
METHODS: We studied depressed patients receiving randomized treatment with venlafaxine or mirtazapine for 28 days.
RESULTS: There was no significant difference between baseline VEGF concentrations in depressed patients compared to healthy controls. We found no significant effect of antidepressant treatment on serum VEGF.
DISCUSSION: In contrast to serum BDNF, VEGF may not be a suitable biomarker for effects of antidepressant treatment with venlafaxine or mirtazapine.