Bilirubin dynamics in the Gunn rat. Dose response of intermittent and continuous phototherapy.

Jaundiced Gunn rats underwent continuous and intermittent phototherapy with white and blue lights. Irradiances ranged from 0.088 to 1.4 mW/cm2 in the blue (415-465 nm) wavelengths. Changes in serum bilirubin concentration were analyzed by a single exponential model. Dose-response curves for 10 days of phototherapy indicated similar logarithmic relationships between light dose and serum bilirubin decline for intermittent and continuous blue light and continuous white light phototherapy. The dose-response curve for intermittent white light showed a low slope and correlation coefficient.