Targeted mutations of genes reveal important roles in palatal development in mice.

The process of palatal development is regulated by growth factors, extracellular matrix (ECM) protein, and cell adhesion molecules, of which disturbance may result in cleft palate. Knockout mice are important animal models for studying the role of genes during palatal development. Therefore, in this review, we will describe genes knockout in mice to reveal the biological mechanisms of these genes in the formation of the cleft palate.