Medycyna wieku rozwojowego · 2000
[Comparison of the early response to natural and synthetic surfactant in premature babies with respiratory distress syndrome].
Клиническое исследованиеКонтролируемое клиническое исследованиеАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Rutkowska M
Аннотация
OBJECTIVES: To compare the early response to natural and synthetic surfactant in premature babies with respiratory distress syndrome (RDS).
METHODS: This is a prospective study of 21 newborns with respiratory distress syndrome treated with natural or synthetic surfactant. The response rapidity after administration of natural or synthetic surfactant was compared by parameters of mechanical ventilation (FiO2, Pmax, IO) in the first 6 hours and during the following 7 days of life. The frequency of respiratory complications, presence of patent ductus arteriosus (PDA) and its treatment and causes of death were evaluated.
RESULTS: Definitely quicker decrease in ventilation parameters was observed after the administration of natural surfactant as compared to the synthetic one. Statistically significant differences were observed during 72 hours and then they decreased.
CONCLUSION: The response after the administration of natural surfactants in premature babies with RDS within the first six hours of treatment was significantly quicker than after synthetic surfactant. This improves the parameters of mechanical ventilation much quicker and prevents complications. Longitudinal studies of the development of children treated with both kinds of surfactant are necessary in order to evaluate the effects of the treatment in the neonatal period.
METHODS: This is a prospective study of 21 newborns with respiratory distress syndrome treated with natural or synthetic surfactant. The response rapidity after administration of natural or synthetic surfactant was compared by parameters of mechanical ventilation (FiO2, Pmax, IO) in the first 6 hours and during the following 7 days of life. The frequency of respiratory complications, presence of patent ductus arteriosus (PDA) and its treatment and causes of death were evaluated.
RESULTS: Definitely quicker decrease in ventilation parameters was observed after the administration of natural surfactant as compared to the synthetic one. Statistically significant differences were observed during 72 hours and then they decreased.
CONCLUSION: The response after the administration of natural surfactants in premature babies with RDS within the first six hours of treatment was significantly quicker than after synthetic surfactant. This improves the parameters of mechanical ventilation much quicker and prevents complications. Longitudinal studies of the development of children treated with both kinds of surfactant are necessary in order to evaluate the effects of the treatment in the neonatal period.