Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology · 2016
THE ROLE OF CALCIUM-REGULATING SYSTEM IN THE PATHOGENESIS AND SANOGENESIS OF PEPTIC ULCER DISEASE AND POSSIBILITY OF ITS CHANGES CORRECTION IN THE TREATMENT OF RECURRENT DISEASE.
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Аннотация
AIM: to determine the condition calcium-regulating system, calcium-phosphate balance in the period of recurrence of peptic ulcer disease and possibility of correction changes in calcium-regulating system (drugs calcitonin, calcium channel-blocking agent, biphosphonate).
MATERIALS AND METHODS: 220 patients with peptic ulcer recurrence were examined with examinations of parathyrin, calcitonin, calcium and phosphorus in blood, secretbry and motor functions of a stomach.
RESULTS: it was established that a recurrence of peptic ulcer disease accompanied by significant increase of parathyrin and calcium in blood, small increase of calcitonin in blood, significant decrease phosphorus in blood. These changes, accompanied by a significant increase of secretory and motor functions of a stomach, reducing production gastromucoproteids. Application in the treatment of peptic ulcer disease calcitrinum, nifedipinum and etidronic acid leads to a significant clinical effect, the normalization of the level of calcium in blood and functions of the stomach.
CONCLUSION: recurrence of peptic ulcer disease has changes in calcium-regulating system. Application in complex treatment of recurrence of peptic hormone C-cells of the thyroid - calcitrinum, calcium channel-blocking agent -- nifedipine and biphosphonate - etidronic acid are clinically effective.
MATERIALS AND METHODS: 220 patients with peptic ulcer recurrence were examined with examinations of parathyrin, calcitonin, calcium and phosphorus in blood, secretbry and motor functions of a stomach.
RESULTS: it was established that a recurrence of peptic ulcer disease accompanied by significant increase of parathyrin and calcium in blood, small increase of calcitonin in blood, significant decrease phosphorus in blood. These changes, accompanied by a significant increase of secretory and motor functions of a stomach, reducing production gastromucoproteids. Application in the treatment of peptic ulcer disease calcitrinum, nifedipinum and etidronic acid leads to a significant clinical effect, the normalization of the level of calcium in blood and functions of the stomach.
CONCLUSION: recurrence of peptic ulcer disease has changes in calcium-regulating system. Application in complex treatment of recurrence of peptic hormone C-cells of the thyroid - calcitrinum, calcium channel-blocking agent -- nifedipine and biphosphonate - etidronic acid are clinically effective.