Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
Association of remnant cholesterol with coronary heart disease and severity of coronary artery stenosis in non-dialysis patients with stage 3-5 chronic kidney disease.
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Mei Xiyue, Wang Yue, Sun Ruizhao, Dong Yanqing, Li Zuolin, Xu Shengchun, Tang Rining, Liu Hong
Аннотация
BACKGROUND AND AIM: Remnant cholesterol (RC) is a risk factor for coronary heart disease (CHD). This study aimed to investigate the association between RC, CHD, and the severity of coronary artery stenosis in patients with stage 3-5 chronic kidney disease (CKD).
METHODS AND RESULTS: We conducted a retrospective study of non-dialysis patients diagnosed with stage 3-5 CKD and suspected CHD who underwent coronary angiography (CAG) at our center between August 2015 and December 2017. CAG was used to diagnose CHD, and the Gensini score was used to quantify the severity of coronary artery stenosis. Of 870 patients included in this study, 659 were diagnosed with CHD. There was no significant difference in the RC concentration between the CHD and non-CHD groups (P = 0.129). Multivariate logistic regression analysis demonstrated that RC was ssociated with CHD (OR 2.733, 95 % CI 1.094-6.825; P = 0.031). Further analysis of the CHD group showed that the Gensini score for severe coronary artery stenosis in the third tertile of the RC concentration (44 [20-86]) was higher than that in the first tertile (36 [15-68]; P = 0.046). After adjusting for potential confounders, the RC level was independently associated with severe coronary artery stenosis (tertile 2 vs. tertile 1: adjusted OR 3.659, 95 % CI 1.231-10.878; P = 0.020; and tertile 3 vs. tertile 1: adjusted OR 5.597, 95 % CI 1.835-17.070; P = 0.002).
CONCLUSIONS: Higher RC levels were independently associated with CHD and severe coronary artery stenosis among non-dialysis patients with stage 3-5 CKD.
METHODS AND RESULTS: We conducted a retrospective study of non-dialysis patients diagnosed with stage 3-5 CKD and suspected CHD who underwent coronary angiography (CAG) at our center between August 2015 and December 2017. CAG was used to diagnose CHD, and the Gensini score was used to quantify the severity of coronary artery stenosis. Of 870 patients included in this study, 659 were diagnosed with CHD. There was no significant difference in the RC concentration between the CHD and non-CHD groups (P = 0.129). Multivariate logistic regression analysis demonstrated that RC was ssociated with CHD (OR 2.733, 95 % CI 1.094-6.825; P = 0.031). Further analysis of the CHD group showed that the Gensini score for severe coronary artery stenosis in the third tertile of the RC concentration (44 [20-86]) was higher than that in the first tertile (36 [15-68]; P = 0.046). After adjusting for potential confounders, the RC level was independently associated with severe coronary artery stenosis (tertile 2 vs. tertile 1: adjusted OR 3.659, 95 % CI 1.231-10.878; P = 0.020; and tertile 3 vs. tertile 1: adjusted OR 5.597, 95 % CI 1.835-17.070; P = 0.002).
CONCLUSIONS: Higher RC levels were independently associated with CHD and severe coronary artery stenosis among non-dialysis patients with stage 3-5 CKD.