Clinical and experimental obstetrics & gynecology · 2011
The role of oral contraception use in the occurrence of breast cancer. A retrospective study of 405 patients.
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Iatrakis G, Iavazzo C, Zervoudis S, Koumousidis A, Sofoudis C, Kalampokas T, Salakos N
Аннотация
UNLABELLED: The investigation of potential predisposing factors of breast cancer, a disease accounting for almost one-third of malignancies in women, is necessary in order to reduce the incidence.
MATERIALS AND METHOD: We interviewed 405 female patients who had been diagnosed with breast cancer and who also reported having used oral contraceptive pills before. They were categorized into two groups (group A < 7 years OC use and group B > 7 years OC use).
RESULTS: Statistical analysis revealed a small (p < 0.02) but significant increased risk of the disease to BRCA mutation carriers, as well as to the women with a significant medical or family history of breast, ovarian or colon cancer who had also previously used oral contraceptive pills for more than seven years.
DISCUSSION: Breast cancer seems to be positively dependent on prolonged oral contraceptive use.
CONCLUSION: More research is needed to establish the hypothesis that the human genome is vulnerable to oral contraceptives.
MATERIALS AND METHOD: We interviewed 405 female patients who had been diagnosed with breast cancer and who also reported having used oral contraceptive pills before. They were categorized into two groups (group A < 7 years OC use and group B > 7 years OC use).
RESULTS: Statistical analysis revealed a small (p < 0.02) but significant increased risk of the disease to BRCA mutation carriers, as well as to the women with a significant medical or family history of breast, ovarian or colon cancer who had also previously used oral contraceptive pills for more than seven years.
DISCUSSION: Breast cancer seems to be positively dependent on prolonged oral contraceptive use.
CONCLUSION: More research is needed to establish the hypothesis that the human genome is vulnerable to oral contraceptives.