Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019
Sensory evoked potentials in patients with Rett syndrome through the lens of animal studies: Systematic review.
СтатьяПоддержка исследования: вне правительства СШАСистематический обзорНазвание и аннотация: Перевод в очереди
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Sysoeva Olga V, Smirnov Kirill, Stroganova Tatiana A
Аннотация
OBJECTIVE: Systematically review the abnormalities in event related potential (ERP) recorded in Rett Syndrome (RTT) patients and animals in search of translational biomarkers of deficits related to the particular neurophysiological processes of known genetic origin (MECP2 mutations).
METHODS: Pubmed, ISI Web of Knowledge and BIORXIV were searched for the relevant articles according to PRISMA standards.
RESULTS: ERP components are generally delayed across all sensory modalities both in RTT patients and its animal model, while findings on ERPs amplitude strongly depend on stimulus properties and presentation rate. Studies on RTT animal models uncovered the abnormalities in the excitatory and inhibitory transmission as critical mechanisms underlying the ERPs changes, but showed that even similar ERP alterations in auditory and visual domains have a diverse neural basis. A range of novel approaches has been developed in animal studies bringing along the meaningful neurophysiological interpretation of ERP measures in RTT patients.
CONCLUSIONS: While there is a clear evidence for sensory ERPs abnormalities in RTT, to further advance the field there is a need in a large-scale ERP studies with the functionally-relevant experimental paradigms.
SIGNIFICANCE: The review provides insights into domain-specific neural basis of the ERP abnormalities and promotes clinical application of the ERP measures as the non-invasive functional biomarkers of RTT pathophysiology.
METHODS: Pubmed, ISI Web of Knowledge and BIORXIV were searched for the relevant articles according to PRISMA standards.
RESULTS: ERP components are generally delayed across all sensory modalities both in RTT patients and its animal model, while findings on ERPs amplitude strongly depend on stimulus properties and presentation rate. Studies on RTT animal models uncovered the abnormalities in the excitatory and inhibitory transmission as critical mechanisms underlying the ERPs changes, but showed that even similar ERP alterations in auditory and visual domains have a diverse neural basis. A range of novel approaches has been developed in animal studies bringing along the meaningful neurophysiological interpretation of ERP measures in RTT patients.
CONCLUSIONS: While there is a clear evidence for sensory ERPs abnormalities in RTT, to further advance the field there is a need in a large-scale ERP studies with the functionally-relevant experimental paradigms.
SIGNIFICANCE: The review provides insights into domain-specific neural basis of the ERP abnormalities and promotes clinical application of the ERP measures as the non-invasive functional biomarkers of RTT pathophysiology.
Предметные рубрики MeSH
Age FactorsAnimalsAuditory CortexBiomarkersDisease Models, AnimalElectroencephalographyElectroencephalography Phase SynchronizationEvoked Potentials, AuditoryEvoked Potentials, SomatosensoryEvoked Potentials, VisualFemaleHippocampusHumansMaleMethyl-CpG-Binding Protein 2MiceMice, KnockoutMutationPerceptual MaskingRett SyndromeSignal-To-Noise RatioVisual Cortex