[Dynamic changes in the heart beat frequency of rabbits to auditory and nociceptive signals against the background of neuroleptic action].

Aminazine and haloperidol exerted different effects upon spontaneous heart rate and the reactivity of cardiovascular system in curarized rabbits during habituation to nociceptive and sound signals: aminazine (8-10 mg/kg) increased the heart rate by 8-12% and completely suppressed the reactivity, whereas haloperidol (0.5-1.7 mg/kg) decreased the heart rate by 5.0-8.5% and considerably enhanced the reactivity to sound and nociceptive signals, prolonging the habituation duration. The biphasic response of the rabbit heart rate reveals a working mechanism of the baroreflex control over emotionally significant and stressful effects.