[Biochemical and sonographic values in early pregnancy in women with a history of early spontaneous abortion].

INTRODUCTION

The aim of this study was to examine interconnections between changes in serum levels of biochemical parameters during pregnancy and sonographic parameters relevant for evaluation of early pregnancy.

MATERIAL AND

METHODS

We analyzed serum levels of human chorionic gonadotropin (hCG), estradiol (E2), progesterone (PRG) and prolactin (PRL) using ELISA method, in cases of complicated pregnancies with symptoms of imminent miscarriage, and in patients with uncomplicated pregnancies. We evaluated their impact on mean gestational sac diameter (MSD), crown-rump length (CRL), inner diameter of the vitelline sac (SV), trophoblast (Trf) thickness and embryonic heart rate (STP). All results were correlated using Pearson's test and regression.

RESULTS

Changes in biochemical parameters of pregnancy correlate significantly with dimensions of analyzed sonographic parameters.

DISCUSSION: Levels of chorionic gonadrotropin affect production of ovarian and placental steroidogenesis. Interrelations were also discussed.

CONCLUSION

Changes in biochemical values of pregnancy hormones affect dimensions of analyzed sonographic parameters. During uncomplicated pregnancy, levels of chorionic gonadotropin, progesterone and estradiol affect mean gestation-sac diameter, embryo length, depth of trophoblast invasion and formation and function of vitelline sac, and thus they alter the embryonic heart rate.