Медицинская библиотека · Movement disorders : official journal of the Movement Disorder Society · 2011

Reproductive factors and Parkinson's disease: a multicenter case-control study.

Nicoletti Alessandra, Nicoletti Giuseppe, Arabia Gennarina, Annesi Grazia, De Mari Michele, Lamberti Paolo, Grasso Lucia, Marconi Roberto, Epifanio Antonio, Morgante Letterio, Cozzolino Autilia, Barone Paolo, Quattrone Aldo, Zappia Mario

СтатьяМногоцентровое исследованиеПеревод в очереди

Аннотация

BACKGROUND

The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD).

METHODS

The FRAGAMP study is a large Italian multicenter case-control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression).

RESULTS

Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24-8.59; P = .01).

CONCLUSIONS

Our data suggest that oral contraceptives could increase the risk of PD.

Для цитирования: Nicoletti Alessandra, Nicoletti Giuseppe, Arabia Gennarina, Annesi Grazia, De Mari Michele, Lamberti Paolo, Grasso Lucia, Marconi Roberto, Epifanio Antonio, Morgante Letterio, Cozzolino Autilia, Barone Paolo, Quattrone Aldo, Zappia Mario. Reproductive factors and Parkinson's disease: a multicenter case-control study.. Movement disorders : official journal of the Movement Disorder Society. 2011. DOI: 10.1002/mds.23951.

Предметные рубрики MeSH

Aged Case-Control Studies Contraceptives, Oral, Hormonal Estrogen Replacement Therapy Estrogens Female Humans Italy Leiomyoma Logistic Models Menopause Middle Aged Multivariate Analysis Parkinson Disease Pregnancy Reproduction Risk Factors Surveys and Questionnaires Uterine Neoplasms

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.