Magnetic resonance in medicine · 2015
Saturation-transfer effects and longitudinal relaxation times of (31) P metabolites in fibroglandular breast tissue at 7T.
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van der Kemp Wybe J M, Wijnen Jannie P, Luijten Peter R, Klomp Dennis W J
Аннотация
PURPOSE: To investigate longitudinal relaxation times and saturation-transfer effects of phosphorous metabolites in breast fibroglandular tissue in vivo with (31) P MR spectroscopy at 7T.
METHODS: Progressive saturation with adiabatic half passage excitation was used to determine T1 values of (31) P metabolites in a group of six healthy volunteers. Saturation-transfer experiments were performed in seven healthy volunteers by saturating at 0 ppm and 10 ppm with sinc-Gaussian pulses (90 ms; 10-ms pulse interval; B1 = 17 μT) prior to excitation. Localization was performed by surface coils and one-dimensional chemical shift imaging. Data were analyzed via spectral fitting with the JMRUI software package, and T1 values were obtained by fitting the data to the signal equation.
RESULTS: The determined longitudinal relaxation time values at 7T were as follows: phosphoethanolamine, 4.0 ± 0.2 s; phosphocholine, 1.8 ± 0.2 s; inorganic phosphate, 6.1 ± 0.1 s; phosphodiesters, glycerophosphatidylethanolamine plus glycerophosphocholine, 2.1 ± 0.1, and glycerophosphatidylethanolamine, 1.5 ± 0.1s; γ-ATP, 2.1 ± 0.1 s; and α-ATP, 2.0 ± 0.1 s. Saturation-transfer measurements with saturation pulses at 0 ppm showed a significant signal reduction in the phosphodiester 2-3 ppm range, whereas the γ-ATP signal at -2.5 ppm was not affected significantly.
CONCLUSION: Longitudinal relaxation times of phosphorous metabolites in fibroglandular tissue revealed relatively low T1 values for phosphodiesters. Saturation-transfer measurements showed that the phosphodiester signals were the only signals that were affected significantly, possibly indicating the presence of mobile phospholipids. Magn Reson Med 76:402-407, 2016. © 2015 Wiley Periodicals, Inc.
METHODS: Progressive saturation with adiabatic half passage excitation was used to determine T1 values of (31) P metabolites in a group of six healthy volunteers. Saturation-transfer experiments were performed in seven healthy volunteers by saturating at 0 ppm and 10 ppm with sinc-Gaussian pulses (90 ms; 10-ms pulse interval; B1 = 17 μT) prior to excitation. Localization was performed by surface coils and one-dimensional chemical shift imaging. Data were analyzed via spectral fitting with the JMRUI software package, and T1 values were obtained by fitting the data to the signal equation.
RESULTS: The determined longitudinal relaxation time values at 7T were as follows: phosphoethanolamine, 4.0 ± 0.2 s; phosphocholine, 1.8 ± 0.2 s; inorganic phosphate, 6.1 ± 0.1 s; phosphodiesters, glycerophosphatidylethanolamine plus glycerophosphocholine, 2.1 ± 0.1, and glycerophosphatidylethanolamine, 1.5 ± 0.1s; γ-ATP, 2.1 ± 0.1 s; and α-ATP, 2.0 ± 0.1 s. Saturation-transfer measurements with saturation pulses at 0 ppm showed a significant signal reduction in the phosphodiester 2-3 ppm range, whereas the γ-ATP signal at -2.5 ppm was not affected significantly.
CONCLUSION: Longitudinal relaxation times of phosphorous metabolites in fibroglandular tissue revealed relatively low T1 values for phosphodiesters. Saturation-transfer measurements showed that the phosphodiester signals were the only signals that were affected significantly, possibly indicating the presence of mobile phospholipids. Magn Reson Med 76:402-407, 2016. © 2015 Wiley Periodicals, Inc.