Journal of orthopaedic trauma · 2016
Do 25-Hydroxyvitamin D Levels Correlate With Fracture Complications?
Контролируемое клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Bodendorfer Blake M, Cook James L, Robertson Daniel S, Della Rocca Gregory J, Volgas David A, Stannard James P, Crist Brett D
Аннотация
OBJECTIVES: To determine the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and the likelihood of postoperative complications and fracture reoperation rate in orthopaedic trauma patients receiving vitamin D and calcium supplementation.
DESIGN: Retrospective case series.
SETTING: Level I trauma center, Midwestern United States.
PATIENTS: All orthopaedic trauma patients-18 years or older-over a 20-month period were included with available initial and repeat 25(OH)D serum levels. In total, 201 patients met inclusion criteria.
INTERVENTION: All patients received 1000 IU of vitamin D3 and 1500 mg of calcium daily. Vitamin D deficient and insufficient patients also received 50,000 IU of ergocalciferol (vitamin D2) weekly until 25(OH)D levels normalized or fractures healed.
MAIN OUTCOME MEASUREMENTS: fracture complications and 25(OH)D levels.
RESULTS: Fifteen patients experienced postoperative healing complications. There was no significant difference between initial (P = 0.92) or repeat (P = 0.91) 25(OH)D levels between patients with and without fracture healing complications. Twenty-eight patients required repeat orthopaedic surgery. There was no significant difference between initial (P = 0.62) or repeat (P = 0.18) 25(OH)D levels between patients who did or did not require repeat orthopaedic surgery. There was no significant difference between initial (P = 0.66) or repeat (P = 0.89) 25(OH)D levels between patients who did or did not require nonorthopaedic surgery.
CONCLUSIONS: Serum 25(OH)D levels did not significantly affect the likelihood of fracture healing complications requiring surgery or any nonorthopaedic injury-related surgery.
LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
DESIGN: Retrospective case series.
SETTING: Level I trauma center, Midwestern United States.
PATIENTS: All orthopaedic trauma patients-18 years or older-over a 20-month period were included with available initial and repeat 25(OH)D serum levels. In total, 201 patients met inclusion criteria.
INTERVENTION: All patients received 1000 IU of vitamin D3 and 1500 mg of calcium daily. Vitamin D deficient and insufficient patients also received 50,000 IU of ergocalciferol (vitamin D2) weekly until 25(OH)D levels normalized or fractures healed.
MAIN OUTCOME MEASUREMENTS: fracture complications and 25(OH)D levels.
RESULTS: Fifteen patients experienced postoperative healing complications. There was no significant difference between initial (P = 0.92) or repeat (P = 0.91) 25(OH)D levels between patients with and without fracture healing complications. Twenty-eight patients required repeat orthopaedic surgery. There was no significant difference between initial (P = 0.62) or repeat (P = 0.18) 25(OH)D levels between patients who did or did not require repeat orthopaedic surgery. There was no significant difference between initial (P = 0.66) or repeat (P = 0.89) 25(OH)D levels between patients who did or did not require nonorthopaedic surgery.
CONCLUSIONS: Serum 25(OH)D levels did not significantly affect the likelihood of fracture healing complications requiring surgery or any nonorthopaedic injury-related surgery.
LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overBiomarkersBone Density Conservation AgentsCalciumFemaleFractures, BoneHumansMaleMiddle AgedMissouriPostoperative ComplicationsPrevalencePrognosisProspective StudiesReoperationReproducibility of ResultsRisk AssessmentSensitivity and SpecificityStatistics as TopicTreatment OutcomeVitamin DYoung Adult