Revista da Sociedade Brasileira de Medicina Tropical · 2020
Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment.
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Oliveira Saulo Gomes de, Souza Ilana Brito Ferraz de, Constantino Taynan da Silva, Silva Paula Carolina Valença, Lima Elker Lene Santos de, Muniz Maria Tereza Cartaxo, Domingues Ana Lúcia Coutinho
Аннотация
INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.
METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.
RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.
CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.
METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.
RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.
CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.