The effect of the reduction method on the composition of 99mTc-EHDP complexes.

The composition of 99mTc-ethane-1-hydroxy-1, 1-diphosphonate complexes, prepared with the reducing agent NaBH4 and by electrolytic reduction, was analysed by reversed-phase ion-pair chromatography and soft-gel permeation chromatography. The results were compared with corresponding data for complexes prepared with the traditional reducing agent tin(II). Significant differences between the chromatograms of the three preparations were found. They were interpreted in terms of the occurrence of different complexes in the three preparations.