Nanomedicine (London, England) · 2011
Novel ferrocenyl nitroxide nanoparticles as electron paramagnetic resonance oximetry probes in vitro and in vivo.
Оценочное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Qiu Xiao, Zhao Hongli, Yu Ronghua, Zhang Jiufeng, Lan Minbo
Аннотация
AIMS: In this article we report our recent developments in the field of electron paramagnetic resonance oximetry.
MATERIALS & METHODS: Novel synthesized ferrocenyl nitroxide radicals (FcN)-1-6 were evaluated to determine their electron paramagnetic resonance oxygen responsiveness and reduction resistance. The 3-ferrocenyl-N-(oxyl-2,2,6,6-tetramethylpiperidin-4-yl) butanamide radical (FcN-6), with outstanding electron paramagnetic resonance oxygen sensitivity, was encapsulated in Pluronic F-127 polymeric nanoparticles.
RESULTS: The nanoparticles exhibited good oxygen sensitivity, long-term stability of responsiveness, targeting to lung, liver and tumor, and low toxicity.
CONCLUSION: These features make this novel nanoparticle especially valuable for mapping O₂ concentrations in the body and monitoring the oxygen level inside tissues.
MATERIALS & METHODS: Novel synthesized ferrocenyl nitroxide radicals (FcN)-1-6 were evaluated to determine their electron paramagnetic resonance oxygen responsiveness and reduction resistance. The 3-ferrocenyl-N-(oxyl-2,2,6,6-tetramethylpiperidin-4-yl) butanamide radical (FcN-6), with outstanding electron paramagnetic resonance oxygen sensitivity, was encapsulated in Pluronic F-127 polymeric nanoparticles.
RESULTS: The nanoparticles exhibited good oxygen sensitivity, long-term stability of responsiveness, targeting to lung, liver and tumor, and low toxicity.
CONCLUSION: These features make this novel nanoparticle especially valuable for mapping O₂ concentrations in the body and monitoring the oxygen level inside tissues.