Медицинская библиотека · Oral diseases · 2012

MSX1 gene polymorphisms in non-syndromic cleft lip and/or palate.

Cardoso M L, Bezerra J F, Oliveira G H M, Soares C D, Oliveira S R, de Souza K S C, da Silva H P V, Silbiger V N, Luchessi A D, Fajardo C M, Hirata R D C, Almeida M G, Hirata M H, Rezende A A

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

The aim of this study was to investigate the contribution of 6 polymorphic variants of the MSX1 gene in non-syndromic cleft lip and/or palate (NSCL/P).

METHODS

Three hundred and fifty-eight individuals (158 NSCL/P cases and 200 controls) were genotyped by TaqMan allelic discrimination using predesigned SNP assays. Statistical analyses were conducted using the software spss 15.0 and the r statistical suite. Haplotype block structure and haplotype frequencies were determined using the Haploview. A P-value of 0.05 and confidence interval of 95% were used for all of statistical tests.

RESULTS

The patients with non-syndromic cleft lip and/or palate were characterized by similar distribution of MSX1 genotypes and allele in comparison to subjects without oral clefts (P > 0.05). Two haplotype blocks were constructed with polymorphisms of MSX1 gene and haplotypes formed showed a similar frequency in patients with and without oral clefts.

CONCLUSIONS

The present study provides no evidence that MSX1 polymorphisms (rs3775261, rs1042484, rs12532, rs6446693, rs4464513 and rs1907998) play a major role in NSCL/P.

Для цитирования: Cardoso M L, Bezerra J F, Oliveira G H M, Soares C D, Oliveira S R, de Souza K S C, da Silva H P V, Silbiger V N, Luchessi A D, Fajardo C M, Hirata R D C, Almeida M G, Hirata M H, Rezende A A. MSX1 gene polymorphisms in non-syndromic cleft lip and/or palate.. Oral diseases. 2012. DOI: 10.1111/odi.12033.

Предметные рубрики MeSH

Case-Control Studies Cleft Lip Cleft Palate Female Humans MSX1 Transcription Factor Male Polymorphism, Single Nucleotide

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