Peptide Nanostructure-Mediated Antibiotic Delivery by Exploiting H2S-Rich Environment in Clinically Relevant Bacterial Cultures.

Stimuli-responsive self-destructing soft structures serve as versatile hosts for the encapsulation of guest molecules. A new paradigm for H2S-responsive structures, based on a modified tripeptide construct, is presented along with microscopy evidence of its time-dependent rupture. As a medicinally interesting application, we employed these commercial antibiotic-loaded soft structures for successful drug release and inhibition of clinically relevant, drug-susceptible, and methicillin-resistant Staphylococcus aureus.