Proceedings of the National Academy of Sciences of the United States of America · 2021
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Zhang Yiwen, Chen Yingshi, Li Yuzhuang, Huang Feng, Luo Baohong, Yuan Yaochang, Xia Baijin, Ma Xiancai, Yang Tao, Yu Fei, Liu Jun, Liu Bingfeng, Song Zheng, Chen Jingliang, Yan Shumei, Wu Liyang, Pan Ting, Zhang Xu, Li Rong, Huang Wenjing, He Xin, Xiao Fei, Zhang Junsong, Zhang Hui
Аннотация
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and has claimed over 2 million lives worldwide. Although the genetic sequences of SARS-CoV and SARS-CoV-2 have high homology, the clinical and pathological characteristics of COVID-19 differ significantly from those of SARS. How and whether SARS-CoV-2 evades (cellular) immune surveillance requires further elucidation. In this study, we show that SARS-CoV-2 infection leads to major histocompability complex class Ι (MHC-Ι) down-regulation both in vitro and in vivo. The viral protein encoded by open reading frame 8 (ORF8) of SARS-CoV-2, which shares the least homology with SARS-CoV among all viral proteins, directly interacts with MHC-Ι molecules and mediates their down-regulation. In ORF8-expressing cells, MHC-Ι molecules are selectively targeted for lysosomal degradation via autophagy. Thus, SARS-CoV-2-infected cells are much less sensitive to lysis by cytotoxic T lymphocytes. Because ORF8 protein impairs the antigen presentation system, inhibition of ORF8 could be a strategy to improve immune surveillance.