Journal of ethnopharmacology · 2008
Antioxidative and hepatoprotective effect of CGX, an herbal medicine, against toxic acute injury in mice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hu Xiao-Ping, Shin Jang-Woo, Wang Jing-Hua, Cho Jung-Hyo, Son Jin-Young, Cho Chong-Kwan, Son Chang-Gue
Аннотация
AIM: CGX, a modified traditional Chinese herbal drug whose name means "liver cleaning," is used to treat various liver disorders. This study investigated the protective effects of CGX and its mechanisms.
MATERIAL AND METHODS: After pretreating ICR mice twice daily with CGX (po, 50 or 100mg/kg) or distilled water for three consecutive days, acute liver injury was induced by a single injection of CCl(4) (ip, 10mL/kg of 0.2% in olive oil) (n=8 per group).
RESULTS: Pretreatment with CGX significantly attenuated the elevation in biochemical parameters, such as alanine transaminase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) in serum, and the malondialdehyde concentrations in liver tissue. Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione (GSH) content, but not superoxide dismutase (SOD) activity, and it inhibited the CCl(4)-induced high expression of iNOS and TNF-alpha in hepatic tissue.
CONCLUSION: This study showed that CGX has hepatoprotective effects against free radical-induced acute injury via primarily antioxidative properties.
MATERIAL AND METHODS: After pretreating ICR mice twice daily with CGX (po, 50 or 100mg/kg) or distilled water for three consecutive days, acute liver injury was induced by a single injection of CCl(4) (ip, 10mL/kg of 0.2% in olive oil) (n=8 per group).
RESULTS: Pretreatment with CGX significantly attenuated the elevation in biochemical parameters, such as alanine transaminase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) in serum, and the malondialdehyde concentrations in liver tissue. Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione (GSH) content, but not superoxide dismutase (SOD) activity, and it inhibited the CCl(4)-induced high expression of iNOS and TNF-alpha in hepatic tissue.
CONCLUSION: This study showed that CGX has hepatoprotective effects against free radical-induced acute injury via primarily antioxidative properties.
Предметные рубрики MeSH
AnimalsAntioxidantsCarbon TetrachlorideCatalaseChemical and Drug Induced Liver InjuryDose-Response Relationship, DrugDrugs, Chinese HerbalGene Expression RegulationGlutathioneLiverLiver Function TestsMaleMiceMice, Inbred ICRNitric Oxide Synthase Type IISuperoxide DismutaseTumor Necrosis Factor-alpha