Pharmacogenomics · 2022
Transcriptional effects of fingolimod treatment on peripheral T cells in relapsing remitting multiple sclerosis patients.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sferruzza Giacomo, Clarelli Ferdinando, Mascia Elisabetta, Ferrè Laura, Ottoboni Linda, Sorosina Melissa, Santoro Silvia, Filippi Massimo, Provero Paolo, Esposito Federica
Аннотация
Aim: To investigate the transcriptional changes induced by Fingolimod (FTY) in T cells of relapsing remitting multiple sclerosis patients. Patients & methods: Transcriptomic changes after 6 months of FTY therapy were evaluated on T cells from 24 relapsing remitting multiple sclerosis patients through RNA-sequencing, followed by technical validation and pathway analysis. Results: Among differentially expressed genes, CX3CR1 and CCR7 resulted strongly up- and downregulated, respectively. Two relevant genes were validated with quantitative PCR and we largely confirmed findings from two previous microarray-based studies with similar design. Pathway analysis pointed to an involvement of processes related to immune function and cell migration. Conclusion: Our data support the evidence that FTY induces major transcriptional changes in genes involved in immune response and cell trafficking in T lymphocytes.