Neuron · 2019
Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАНазвание и аннотация: Перевод в очереди
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Greene Deanna J, Marek Scott, Gordon Evan M, Siegel Joshua S, Gratton Caterina, Laumann Timothy O, Gilmore Adrian W, Berg Jeffrey J, Nguyen Annie L, Dierker Donna, Van Andrew N, Ortega Mario, Newbold Dillan J, Hampton Jacqueline M, Nielsen Ashley N, McDermott Kathleen B, Roland Jarod L, Norris Scott A, Nelson Steven M, Snyder Abraham Z, Schlaggar Bradley L, Petersen Steven E, Dosenbach Nico U F
Аннотация
The basal ganglia, thalamus, and cerebral cortex form an interconnected network implicated in many neurological and psychiatric illnesses. A better understanding of cortico-subcortical circuits in individuals will aid in development of personalized treatments. Using precision functional mapping-individual-specific analysis of highly sampled human participants-we investigated individual-specific functional connectivity between subcortical structures and cortical functional networks. This approach revealed distinct subcortical zones of network specificity and multi-network integration. Integration zones were systematic, with convergence of cingulo-opercular control and somatomotor networks in the ventral intermediate thalamus (motor integration zones), dorsal attention and visual networks in the pulvinar, and default mode and multiple control networks in the caudate nucleus. The motor integration zones were present in every individual and correspond to consistently successful sites of deep brain stimulation (DBS; essential tremor). Individually variable subcortical zones correspond to DBS sites with less consistent treatment effects, highlighting the importance of PFM for neurosurgery, neurology, and psychiatry.