Effect of propranolol, histidine, and trimethylhydrazine propionate on the capacity of epinephrine to change the rate of erythrocyte agglutination.

We studied the effects of analogues of endogenous sensitizer of β-adrenergic receptors histidine (10(-4) g/ml) and mildronate (10(-5) g/ml) and endogenous β-adrenoreceptor blocker propranolol (10(-6) g/ml) on adrenoreactivity of erythrocytes in men assessed by changes in the rate of erythrocyte agglutination under the influence of epinephrine (10(-10)-10(-6) g/ml). Epinephrine increased the rate of agglutination, which attested to predominance of α1-adrenoceptors. Propranolol enhanced the effect of epinephrine, while histidine and mildronate reduced it. Hence, endogenous modulators of adrenoceptors can modify adrenoreactivity of erythrocytes and probably other cells, and erythrocytes can serve as indicator of instant adrenoreactivity of body cells.