The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2011
Asymptomatic bacteriuria in users of low-dose combined oral contraceptives.
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Nassaji Mohammad, Ghorbani Raheb
Аннотация
OBJECTIVES: To investigate the association between oral contraceptive use and the prevalence of asymptomatic bacteriuria in women.
METHODS: The study was conducted on healthy women of childbearing age who either used low-dose combined oral contraceptives (COCs; cases) or applied the withdrawal method (controls). A positive urine culture with a colony count of more than 10(5)/ml, with the same bacteria on two consecutive specimens, was defined as asymptomatic bacteriuria. Pyuria was defined as the presence of ≥ 10 leukocytes per mm3 of urine.
RESULTS: Overall, 369 women in the COC group and 364 in the control group were evaluated. The mean ages of women in the COC group and of controls were 29.9 ± 5.4 years and 30.4 ± 6.0 years, respectively (p = 0.280). Asymptomatic bacteriuria was detected in 2.4% of COC users and 1.9% of the controls (p = 0.633). Pyuria was found in 16% of the cases and 18.1% of the controls (p = 0.441). None of these differences was statistically significant. There was no significant association between duration of COC usage (< 1 year vs. ≥ 1 year) and asymptomatic bacteriuria.
CONCLUSION: Use of low-dose COCs (even long-term) does not increase the risk of asymptomatic bacteriuria.
METHODS: The study was conducted on healthy women of childbearing age who either used low-dose combined oral contraceptives (COCs; cases) or applied the withdrawal method (controls). A positive urine culture with a colony count of more than 10(5)/ml, with the same bacteria on two consecutive specimens, was defined as asymptomatic bacteriuria. Pyuria was defined as the presence of ≥ 10 leukocytes per mm3 of urine.
RESULTS: Overall, 369 women in the COC group and 364 in the control group were evaluated. The mean ages of women in the COC group and of controls were 29.9 ± 5.4 years and 30.4 ± 6.0 years, respectively (p = 0.280). Asymptomatic bacteriuria was detected in 2.4% of COC users and 1.9% of the controls (p = 0.633). Pyuria was found in 16% of the cases and 18.1% of the controls (p = 0.441). None of these differences was statistically significant. There was no significant association between duration of COC usage (< 1 year vs. ≥ 1 year) and asymptomatic bacteriuria.
CONCLUSION: Use of low-dose COCs (even long-term) does not increase the risk of asymptomatic bacteriuria.