American journal of infection control · 2025
Outbreak of adenovirus type-8 conjunctivitis among healthcare workers in the ophthalmology clinic of a tertiary hospital: Management and infection control measures.
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Memişoğlu Funda, Yilmaz Zeynep Burcin, Yakupoğulları Yusuf, Toplu Sibel Altunışık, Tanrıverdi Elif Seren, Cumurcu Tongabay, Otlu Barış
Аннотация
BACKGROUND: This study documents an outbreak of Human adenovirus (HAdV) keratoconjunctivitis originating in the ophthalmology department of a tertiary hospital and spreading to the neonatal intensive care unit.
METHODS: Following ORION guidelines, the Hospital Infection Control Committee launched an investigation after clusters of keratoconjunctivitis in healthcare workers reported over 4-week. Patient records were reviewed, environmental and patient samples collected, and PCR analyses performed. Infection control measures were implemented, and their effectiveness was assessed through follow-up testing. The institutional burden of the outbreak was analyzed.
RESULTS: Twelve healthcare workers were affected (8 ophthalmology, 4 neonatal intensive care unit). PCR confirmed HAdV in conjunctival swabs from 11 tested individuals, including cases infected more than 3 weeks earlier. Viral contamination was detected on 10/16 environmental surfaces in the ophthalmology clinic. Genotyping identified HAdV type-8. The outbreak imposed major operational burdens, especially workforce loss. Chlorine solution achieved rapid surface disinfection, while 0.36% hydrogen peroxide required repeated applications for chlorine-sensitive devices. Following enhanced disinfection protocols and temporary clinic closure during a holiday, no new cases occurred.
DISCUSSION: This outbreak, which continued until the Infection Control Committee intervened, underlines the high environmental contamination of HAdV and the critical importance of a swift, evidence-based, and multidisciplinary response.
CONCLUSIONS: This study demonstrates that targeted disinfection and strict Infection control measures are essential for containing such outbreaks and mitigating their significant operational and financial impact on healthcare institutions.
METHODS: Following ORION guidelines, the Hospital Infection Control Committee launched an investigation after clusters of keratoconjunctivitis in healthcare workers reported over 4-week. Patient records were reviewed, environmental and patient samples collected, and PCR analyses performed. Infection control measures were implemented, and their effectiveness was assessed through follow-up testing. The institutional burden of the outbreak was analyzed.
RESULTS: Twelve healthcare workers were affected (8 ophthalmology, 4 neonatal intensive care unit). PCR confirmed HAdV in conjunctival swabs from 11 tested individuals, including cases infected more than 3 weeks earlier. Viral contamination was detected on 10/16 environmental surfaces in the ophthalmology clinic. Genotyping identified HAdV type-8. The outbreak imposed major operational burdens, especially workforce loss. Chlorine solution achieved rapid surface disinfection, while 0.36% hydrogen peroxide required repeated applications for chlorine-sensitive devices. Following enhanced disinfection protocols and temporary clinic closure during a holiday, no new cases occurred.
DISCUSSION: This outbreak, which continued until the Infection Control Committee intervened, underlines the high environmental contamination of HAdV and the critical importance of a swift, evidence-based, and multidisciplinary response.
CONCLUSIONS: This study demonstrates that targeted disinfection and strict Infection control measures are essential for containing such outbreaks and mitigating their significant operational and financial impact on healthcare institutions.