Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2015
A score for estimating survival in idiopathic pulmonary fibrosis with rest SpO2>88.
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Soares Maria Raquel, Pereira Carlos, Ferreira Rimarcs, Nei Aparecida Martins Coletta Ester, Silva Lima Mariana, Muller Storrer Karin
Аннотация
BACKGROUND: Prediction models for survival at baseline evaluation have been proposed in IPF but some are difficult to use. The aim of present study was to develop a new mortality risk scoring system for patients with IPF at initial evaluation.
METHODS: One hundred twenty with definitive IPF were selected through a review of standardized medical records for interstitial lung diseases. Patients with resting SpO2<89% were excluded. Significant individual predictors we derived by a Cox proportional hazards model and transformed in categorical data according to cut-off points. Beta coefficients for each predictor were similar, so a score was created considering the sum of dichotomic (0 or 1) transformed variables.
FINDINGS: Median follow-up time was 37.5 months. At the end of follow-up, 80 patients had died. Independent predictors of mortality by multivariate analysis included dyspnea (at rest or to light or moderate activities), FVC<70%,FEV1/FVC>0.89 and DLCO ≤ 40%. Resting SpO2 and ExSpO2 were excluded in final analysis. The hazard ratios ranged from 1.95 for dyspnoea to 2.30 for DLCO. When the total score was 0 (Stage I, n=28), median survival time was 68 months; when 1 or 2 (Stage II, n=69), it was 45 months; and when 3 or 4 (Stage III, n=23), it was 19 months (log rank= 60.44, p<0.001).
INTERPRETATION: The score can separate IPF patients with high, intermediate and low survival.
METHODS: One hundred twenty with definitive IPF were selected through a review of standardized medical records for interstitial lung diseases. Patients with resting SpO2<89% were excluded. Significant individual predictors we derived by a Cox proportional hazards model and transformed in categorical data according to cut-off points. Beta coefficients for each predictor were similar, so a score was created considering the sum of dichotomic (0 or 1) transformed variables.
FINDINGS: Median follow-up time was 37.5 months. At the end of follow-up, 80 patients had died. Independent predictors of mortality by multivariate analysis included dyspnea (at rest or to light or moderate activities), FVC<70%,FEV1/FVC>0.89 and DLCO ≤ 40%. Resting SpO2 and ExSpO2 were excluded in final analysis. The hazard ratios ranged from 1.95 for dyspnoea to 2.30 for DLCO. When the total score was 0 (Stage I, n=28), median survival time was 68 months; when 1 or 2 (Stage II, n=69), it was 45 months; and when 3 or 4 (Stage III, n=23), it was 19 months (log rank= 60.44, p<0.001).
INTERPRETATION: The score can separate IPF patients with high, intermediate and low survival.
Предметные рубрики MeSH
Age FactorsCause of DeathCohort StudiesDatabases, FactualDisease ProgressionFemaleHumansIdiopathic Pulmonary FibrosisKaplan-Meier EstimateMaleMultivariate AnalysisOximetryOxygenOxygen ConsumptionPredictive Value of TestsProportional Hazards ModelsROC CurveRespiratory Function TestsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex FactorsSurvival AnalysisTomography, X-Ray ComputedVital Capacity