Медицинская библиотека · Microcirculation (New York, N.Y. : 1994) · 2020

Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study.

Sörensen Ben M, van der Heide Frank C T, Houben Alfons J H M, Koster Annemarie, T J M Berendschot Tos, S A G Schouten Jan, Kroon Abraham A, van der Kallen Carla J H, Henry Ronald M A, van Dongen Martien C J M, J P M Eussen Simone, H C M Savelberg Hans, van der Berg Julianne D, Schaper Nicolaas C, Schram Miranda T, Stehouwer Coen D A

СтатьяМногоцентровое исследованиеНаблюдательное исследованиеПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

Physical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function.

METHODS

In The Maastricht Study, a population-based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 ± 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer-assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes.

RESULTS

In individuals with type 2 diabetes, total physical activity and higher-intensity physical activity were independently associated with greater heat-induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher-intensity physical activity were not associated with heat-induced skin hyperemia. No associations with retinal arteriolar %-dilation were identified.

CONCLUSION

Higher levels of total and higher-intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.

Для цитирования: Sörensen Ben M, van der Heide Frank C T, Houben Alfons J H M, Koster Annemarie, T J M Berendschot Tos, S A G Schouten Jan, Kroon Abraham A, van der Kallen Carla J H, Henry Ronald M A, van Dongen Martien C J M, J P M Eussen Simone, H C M Savelberg Hans, van der Berg Julianne D, Schaper Nicolaas C, Schram Miranda T, Stehouwer Coen D A. Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes-The Maastricht Study.. Microcirculation (New York, N.Y. : 1994). 2020. DOI: 10.1111/micc.12611.

Предметные рубрики MeSH

Adult Aged Diabetes Mellitus, Type 2 Exercise Female Humans Male Microcirculation Middle Aged Prospective Studies Skin

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