[Study on relationship of activated protein C resistance and recurrent spontaneous abortion].

OBJECTIVE

To investigate whether activated protein C resistance (APC-R) is associated with recurrent spontaneous abortion.

METHODS

APC-R was detected by activated partial thromboplastin time (APTT) in the presence and absence of APC. Subjects included 40 nonpregnant parous women (control group) and 55 patients with recurrent spontaneous abortion.

RESULTS

There was significant difference for APC-R between controls and the patients (P < 0.01). Among the study group, the prevalence of APC-R positive rate had no relation to the numbers of abortion. The positive rate of APC-R in patients with late abortion was significantly higher than those with only early abortion (38% and 12% respectively).

CONCLUSION

APC-R is partly associated with recurrent spontaneous abortion, especially late abortion. It has no relation to the numbers of abortion.