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DOI 10.1016/j.jfma.2019.03.005

Медицинская библиотека · Journal of the Formosan Medical Association = Taiwan yi zhi · 2019

Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease.

Fan Pei-Chun, Chang Jason Chih-Hsiang, Lin Chia-Ni, Lee Cheng-Chia, Chen Yi-Ting, Chu Pao-Hsien, Kou George, Lu Yueh-An, Yang Chih-Wei, Chen Yung-Chang

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Аннотация

BACKGROUND/PURPOSE: Indoxyl sulfate (IS) is a protein-binding molecule that exhibits cardiovascular (CV) toxicity. This study determined whether the serum IS level can be used to predict the risk of major adverse CV events (MACEs) in patients with chronic kidney disease (CKD).

METHODS

We studied 147 patients with CKD stage 1-5 over a 3-year follow-up period. IS was measured through mass spectrometry. Patients' demographics were collected and analyzed to predict outcomes by using multivariable Cox regression.

RESULTS

Forty-seven (32.0%) patients had MACEs. IS remained significantly associated with MACEs after multivariable regression analysis. The area under the receiver operating characteristic curve for IS levels was 0.708 (95% confidence interval: 0.618-0.798).

CONCLUSION

IS may have a critical role in the prediction of CV disease in patients with CKD. Further large-scale investigations are warranted and suggested.

Для цитирования: Fan Pei-Chun, Chang Jason Chih-Hsiang, Lin Chia-Ni, Lee Cheng-Chia, Chen Yi-Ting, Chu Pao-Hsien, Kou George, Lu Yueh-An, Yang Chih-Wei, Chen Yung-Chang. Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease.. Journal of the Formosan Medical Association = Taiwan yi zhi. 2019. DOI: 10.1016/j.jfma.2019.03.005.

Предметные рубрики MeSH

AgedAged, 80 and overCardiovascular DiseasesDisease ProgressionFemaleHumansIndicanMaleMass SpectrometryMiddle AgedMultivariate AnalysisROC CurveRenal Insufficiency, ChronicTaiwanTertiary Care Centers
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