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DOI 10.1016/j.chom.2017.02.013

Медицинская библиотека · Cell host & microbe · 2017

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence.

Bugaytsova Jeanna A, Björnham Oscar, Chernov Yevgen A, Gideonsson Pär, Henriksson Sara, Mendez Melissa, Sjöström Rolf, Mahdavi Jafar, Shevtsova Anna, Ilver Dag, Moonens Kristof, Quintana-Hayashi Macarena P, Moskalenko Roman, Aisenbrey Christopher, Bylund Göran, Schmidt Alexej, Åberg Anna, Brännström Kristoffer, Königer Verena, Vikström Susanne, Rakhimova Lena, Hofer Anders, Ögren Johan, Liu Hui, Goldman Matthew D, Whitmire Jeannette M, Ådén Jörgen, Younson Justine, Kelly Charles G, Gilman Robert H, Chowdhury Abhijit, Mukhopadhyay Asish K, Nair G Balakrish, Papadakos Konstantinos S, Martinez-Gonzalez Beatriz, Sgouras Dionyssios N, Engstrand Lars, Unemo Magnus, Danielsson Dan, Suerbaum Sebastian, Oscarson Stefan, Morozova-Roche Ludmilla A, Olofsson Anders, Gröbner Gerhard, Holgersson Jan, Esberg Anders, Strömberg Nicklas, Landström Maréne, Eldridge Angela M, Chromy Brett A, Hansen Lori M, Solnick Jay V, Lindén Sara K, Haas Rainer, Dubois Andre, Merrell D Scott, Schedin Staffan, Remaut Han, Arnqvist Anna, Berg Douglas E, Borén Thomas

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Аннотация

The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.

Для цитирования: Bugaytsova Jeanna A, Björnham Oscar, Chernov Yevgen A, Gideonsson Pär, Henriksson Sara, Mendez Melissa, Sjöström Rolf, Mahdavi Jafar, Shevtsova Anna, Ilver Dag, Moonens Kristof, Quintana-Hayashi Macarena P, Moskalenko Roman, Aisenbrey Christopher, Bylund Göran, Schmidt Alexej, Åberg Anna, Brännström Kristoffer, Königer Verena, Vikström Susanne, Rakhimova Lena, Hofer Anders, Ögren Johan, Liu Hui, Goldman Matthew D, Whitmire Jeannette M, Ådén Jörgen, Younson Justine, Kelly Charles G, Gilman Robert H, Chowdhury Abhijit, Mukhopadhyay Asish K, Nair G Balakrish, Papadakos Konstantinos S, Martinez-Gonzalez Beatriz, Sgouras Dionyssios N, Engstrand Lars, Unemo Magnus, Danielsson Dan, Suerbaum Sebastian, Oscarson Stefan, Morozova-Roche Ludmilla A, Olofsson Anders, Gröbner Gerhard, Holgersson Jan, Esberg Anders, Strömberg Nicklas, Landström Maréne, Eldridge Angela M, Chromy Brett A, Hansen Lori M, Solnick Jay V, Lindén Sara K, Haas Rainer, Dubois Andre, Merrell D Scott, Schedin Staffan, Remaut Han, Arnqvist Anna, Berg Douglas E, Borén Thomas. Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence.. Cell host & microbe. 2017. DOI: 10.1016/j.chom.2017.02.013.

Предметные рубрики MeSH

Adhesins, BacterialBacterial AdhesionGastric MucosaHelicobacter InfectionsHelicobacter pyloriHydrogen-Ion Concentration
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