Dissolution studies of drug formulations using ion-selective electrodes as sensors in an air-segmented continuous flow analyzer.

The application of drug ion-selective electrodes as sensors for the direct determination of the released drug in a continuous-flow analyzer for automated dissolution studies is described. Flow-through electrodes, selective to chlorpromazine, amitriptyline, propantheline, cimetidine, and ranitidine, have been constructed and used for the dissolution studies of 18 dosage forms using the rotating basket apparatus. The dissolution profiles are obtained in the form of potential peaks versus time.