Optimal management of uncomplicated skin and skin structure infections of the lower extremity.

Uncomplicated skin and skin structure infections of the lower extremity are almost always curable when properly diagnosed and promptly treated with antibiotics, but they can cause serious complications if not treated appropriately. These infections are caused often by Staphylococcus aureus and less commonly by Streptococcus pyogenes. Initial treatment is usually empiric. Although the most suitable oral treatment is likely cephalosporin, other options include beta-lactamase inhibitor-penicillin combinations and penicillinase-resistant penicillins. In some cases, incision and drainage or debridement may be required.