Zhonghua fu chan ke za zhi · 1999
[Preliminary study on the relationship between human histocompatibility leukocyte antigen-G mRNA and recurrent spontaneous abortion].
Сравнительное исследованиеАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Zhang X, Fan L, Xu L
Аннотация
OBJECTIVE: To examine the expression of Human Histocompatibility Leukocyte Antigen-G (HLA-G) mRNA in placenta from cases of recurrent spontaneous abortion (RSA) and try to study the relationship between HLA-G mRNA and RSA.
METHODS: In situ hybridization was performed on maternal-fetal interface sections of placenta in first trimester, third trimester of normal pregnancy and RSA women who were treated with immunotherapy and had term delivery.
RESULTS: The positive signal of HLA-G expression were showed in all placentas of normal pregnant women within villus and cytoplasma of syncytiotrophoblast and cytotrophoblast. However, there is no any HLA-G mRNA signals in placentas of RSA women after immunotherapy.
CONCLUSIONS: HLA-G mRNA is not the main cause of RSA and there is no direct relations to fetal survival.
METHODS: In situ hybridization was performed on maternal-fetal interface sections of placenta in first trimester, third trimester of normal pregnancy and RSA women who were treated with immunotherapy and had term delivery.
RESULTS: The positive signal of HLA-G expression were showed in all placentas of normal pregnant women within villus and cytoplasma of syncytiotrophoblast and cytotrophoblast. However, there is no any HLA-G mRNA signals in placentas of RSA women after immunotherapy.
CONCLUSIONS: HLA-G mRNA is not the main cause of RSA and there is no direct relations to fetal survival.