Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes · 2008
Effects of gamma-hexachlorocyclohexane on apoptosis induced by serum deprivation in PC12 cells.
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Aoki Kentaro, Egawa Mari, Saito Takeshi, Hosokawa Toshiyuki, Kurasaki Masaaki
Аннотация
The effects of gamma-hexachlorocyclohexane, one of the endocrine disrupters, widely used for agricultural and medicinal purpose, on apoptosis in PC12 cells were investigated using western blotting analysis and reverse transcriptase-DNA polymerase chain reaction (RT-PCR) method. Apoptosis is a fundamental process necessary for development of individuals and organs. Although gamma -HCH at high concentration did not have an effect on cell viability and apoptosis, DNA fragmentation was slightly enhanced, and apoptotic factors; Bax, Bad, cytochrome c and caspase-3 showed tendency to increase by the addition of a low dose of gamma-HCH to the cell medium. However these changes were not statistically significant. It was concluded that gamma -HCH did not affect on apoptosis in the PC12 cell line system, although gamma -HCH has been reported to induce apoptosis in other cell lines.