[EFFECT OF FLIXOTIDE ON ELECTRON-MICROSCOPIC CHANGES IN LUNG TISSUE OF GUINEA PIGS WITH BRONCHIAL ASTHMA MODEL.].

Chronic experiments on nonlinear short-hair guinea pigs with bronchial asthma model caused by administration of ovalbumin without treatment showed the ap- pearance of electron-microscopic changes of the lungs tissue in the form of chronic allergic inflammation. Significant changes in air - blood barrier with a loo- sening of intercellular contacts, degenerative changes in alveolocytes, and circulatory disorders with symptoms of vascular dilatation and stasis of blood cor- puscles were revealed. Treatment with inhaled fluticasone propionate in the form of flixotide preparation (GlaxoSmithKline, UK) for 3 months (2 times a day for 30 - 45 sec) partially reduced disorders of circulation and transcapillary exchange, decreased edema and degenerative changes in the cells, and restored in- tercellular contacts and pinocytic activity of the air - blood barrier. The obtained results show the expediency of further studies for determining the optimal du- ration of basic treatment during remission of bronchial asthma.