Nanomedicine (London, England) · 2017
Self-targeted salinomycin-loaded DSPE-PEG-methotrexate nanomicelles for targeting both head and neck squamous cell carcinoma cancer cells and cancer stem cells.
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Zhu Minhui, Chen Shicai, Hua Libo, Zhang Caiyun, Chen Mengjie, Chen Donghui, Dong Yinmei, Zhang Yingying, Li Meng, Song Xianmin, Chen Huaiwen, Zheng Hongliang
Аннотация
AIM: To target both head and neck squamous cell carcinoma (HNSCC) cells and cancer stem cells (CSCs) by salinomycin-loaded DSPE-PEG-MTX (synthesized using DSPE-PEG2000-NH2 and methotrexate) nanomicelles (M-SAL-MTX).
MATERIALS & METHODS: The characterization, antitumor activity and mechanism of M-SAL-MTX were evaluated.
RESULTS & CONCLUSION: M-SAL-MTX showed enhanced inhibitory effect toward both HNSCC CSCs and non-CSCs compared with a single treatment of methotrexate and salinomycin. In nude mice-bearing HNSCC xenografts, M-SAL-MTX suppressed tumor growth more effectively than other controls including combination of methotrexate and salinomycin. Therefore, M-SAL-MTX may provide a strategy for treating HNSCC by targeting both HNSCC CSCs and HNSCC cells.
MATERIALS & METHODS: The characterization, antitumor activity and mechanism of M-SAL-MTX were evaluated.
RESULTS & CONCLUSION: M-SAL-MTX showed enhanced inhibitory effect toward both HNSCC CSCs and non-CSCs compared with a single treatment of methotrexate and salinomycin. In nude mice-bearing HNSCC xenografts, M-SAL-MTX suppressed tumor growth more effectively than other controls including combination of methotrexate and salinomycin. Therefore, M-SAL-MTX may provide a strategy for treating HNSCC by targeting both HNSCC CSCs and HNSCC cells.
Предметные рубрики MeSH
AnimalsAnti-Bacterial AgentsAntimetabolites, AntineoplasticCarcinoma, Squamous CellCell Line, TumorDrug CarriersDrug Delivery SystemsHead and Neck NeoplasmsHumansMaleMethotrexateMice, Inbred BALB CMice, NudeMicellesNeoplastic Stem CellsPhosphatidylethanolaminesPolyethylene GlycolsPyransSquamous Cell Carcinoma of Head and NeckPolyether Polyketides