The effect of bucolome on the blood circulation of splanchnic organs in rats with and without pentobarbitone anesthesia.

Using carbonized microspheres, either 15 microns or 50 microns in diameter and labeled with 85Sr, 51Cr or 141Ce, the effect of bucolome (1-cyclohexyl-5-n-butyl-2-, 4, 6-trioxoperhydropyrimidine), a non-steroid anti-inflammatory agent and potent choleretic, on the splanchnic blood circulation was studied in rats with and without pentobarbitone sodium anesthesia. Pentobarbitone sodium caused a significant increase in the distribution of cardiac output in the major splanchnic organs, in particular in the small and large intestines. An i.p. injection of bucolome (20 mg/100 g) produced a significant increase in the cardiac output distribution in the small intestine, and a significant decrease in the pancreatic fraction in both rat groups with and without pentobarbitone anesthesia, in spite of the large increase in the base-line values caused by anesthesia.