FEBS letters · 2007
Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats.
СтатьяНазвание и аннотация: Перевод в очереди
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Kume Yukio, Ikeda Hitoshi, Inoue Morihiro, Tejima Kazuaki, Tomiya Tomoaki, Nishikawa Takako, Watanabe Naoko, Ichikawa Tatsuya, Kaneko Makoto, Okubo Shigeo, Yokota Hiromitsu, Omata Masao, Fujiwara Kenji, Yatomi Yutaka
Аннотация
ADAMTS13 is gaining attention, because its deficiency causes thrombotic thrombocytopenic purpura. Although its regulatory mechanism is not fully understood, we wondered if hepatic stellate cells (HSCs) play a role, because ADAMTS13 mRNA is exclusively expressed in the liver and primarily in HSCs. Plasma ADAMTS13 activity was markedly reduced in dimethylnitrosamine-treated rats, where HSC apoptosis is an essential event, but not in carbon tetrachloride- or thioacetamide-treated rats without HSC apoptosis. Furthermore, plasma ADAMTS13 activity was also reduced in 70% hepatectomized rats, where HSC loss occurs. These results suggest that HSC may be involved in the regulation of plasma ADAMTS13 activity.