Fertility and sterility · 2015
Should progesterone on the human chorionic gonadotropin day still be measured?
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Martinez Francisca, Rodriguez Ignacio, Devesa Marta, Buxaderas Rosario, Gómez Maria José, Coroleu Buenaventura
Аннотация
OBJECTIVE: To evaluate in our setting whether there is currently a level of P on the hCG day (P-hCG) predictive of no pregnancy.
DESIGN: Observational study of prospectively collected data of the P-hCG levels of stimulated IVF cycles.
SETTING: In vitro fertilization unit.
PATIENT(S): All cycles of IVF/intracytoplasmic sperm injection with fresh embryo transfer performed between January 2009 and March 2014.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Pregnancy rate.
RESULT(S): Clinical pregnancy rate per ET was 38.7% and live birth rate was 29.1%. The P-hCG concentration was positively correlated to E2 on the hCG day, and the number of oocytes was negatively correlated to age. Progesterone on hCG day was higher among agonist- compared with antagonist-treated patients (mean ± SD: 1.13 ± 0.69 ng/mL vs. 0.97 ± 0.50 ng/mL) and among recombinant FSH compared with recombinant FSH + hMG stimulation (mean ± SD: 1.11 ± 0.58 ng/mL vs. 0.94 ± 0.50 ng/mL). Pregnancy rate was positively associated with the number of oocytes. There was no correlation between P-hCG value and pregnancy rate, overall or according to the type of treatment.
CONCLUSION(S): In our setting there is no P-hCG value differentiating a good from a poor cycle success rate.
CLINICAL TRIAL REGISTRATION NUMBER: NCT02323347.
DESIGN: Observational study of prospectively collected data of the P-hCG levels of stimulated IVF cycles.
SETTING: In vitro fertilization unit.
PATIENT(S): All cycles of IVF/intracytoplasmic sperm injection with fresh embryo transfer performed between January 2009 and March 2014.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Pregnancy rate.
RESULT(S): Clinical pregnancy rate per ET was 38.7% and live birth rate was 29.1%. The P-hCG concentration was positively correlated to E2 on the hCG day, and the number of oocytes was negatively correlated to age. Progesterone on hCG day was higher among agonist- compared with antagonist-treated patients (mean ± SD: 1.13 ± 0.69 ng/mL vs. 0.97 ± 0.50 ng/mL) and among recombinant FSH compared with recombinant FSH + hMG stimulation (mean ± SD: 1.11 ± 0.58 ng/mL vs. 0.94 ± 0.50 ng/mL). Pregnancy rate was positively associated with the number of oocytes. There was no correlation between P-hCG value and pregnancy rate, overall or according to the type of treatment.
CONCLUSION(S): In our setting there is no P-hCG value differentiating a good from a poor cycle success rate.
CLINICAL TRIAL REGISTRATION NUMBER: NCT02323347.