Difluoromethylarylation of Alkynes from [Bis(difluoroacetoxy)iodo]benzene: Access to CF2H-Containing Dibenzazepines.

A photoinduced radical difluoromethylarylation via tandem addition-cyclization of alkynes with easily available [bis(difluoroacetoxy)iodo]benzene is accomplished, providing a straightforward and practical route for the construction of difluoromethylated dibenzazepines. Various sensitive functional groups can be compatible under photoinduced conditions. Mechanism investigation reveals that this transformation is initiated by the addition of alkyne with difluoromethyl radical, generated in situ from [bis(difluoroacetoxy)iodo]benzene.