[Fertility after chemotherapy of gestational trophoblastic disease].

OBJECTIVE

To evaluate subsequent pregnancy experience in patients following chemotherapy for malignant form of gestational trophoblastic disease.

DESIGN

Retrospective clinical study.

SETTING

Slovak Center of Trophoblastic Disease, Bratislava, Slovak Republic.

METHODS

There were evaluated subsequent pregnancy experiences in 38 patients after chemotherapy for malignant form of gestational trophoblastic disease registered in Slovak center of gestational trophoblastic disease. Histological and cytogenetical analysis of all placentas after deliveries and material from curettage specimens after miscarriages, abortions and ectopic pregnancies were performed.

RESULTS

11 women conceived following successful chemotherapy of gestational trophoblastic disease became pregnant a total 19 times. Out of them there were 9 full-term deliveries, 2 spontaneous abortion, 1 ended in ectopic pregnancy and 7 pregnancies were terminated in therapeutic abortion. Cytogenetical analysis was successful in 7 to 10 reproductive losses with normal karyotype in all analysed cases.

CONCLUSION

Patients after successful chemotherapy of gestational trophoblastic disease have a normal reproductive outcome.