Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2006
[Histological observations of chemically induced acute hepatic injury repaired by allogeneic bone marrow stem cell transplantation].
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Liu Sheng-jun, Fang Chi-hua, Chen Xiao-wu, Rong Zhen-xiang, Zhu Da-jian
Аннотация
OBJECTIVE: To explore the possibility of repairing chemically induced acute hepatic injuries with allogeneic bone marrow stem cell (BMSC) transplantation.
METHODS: A SD rat model of CCl(4)-induced acute hepatic injury was established, which received transplantation of BMSCs (2.0 ml, 1x10(6)/ml) or normal saline injection into the local liver parenchyma, respectively. The rats were sacrificed at 6 h before and 6 h, 1, and 5 weeks after transplantation, and the livers were prepared for microscopic examination.
RESULTS: Cellular necrosis, bridging necrosis, congestion in the hepatic sinusoid, and inflammatory cell infiltration were seen in the chemically injured livers 6 h after model establishment, and these changes were ameliorated in rats receiving BMSC transplantation.
CONCLUSIONS: Allogeneic BMSC transplantation can repair chemically induced acute liver injuries.
METHODS: A SD rat model of CCl(4)-induced acute hepatic injury was established, which received transplantation of BMSCs (2.0 ml, 1x10(6)/ml) or normal saline injection into the local liver parenchyma, respectively. The rats were sacrificed at 6 h before and 6 h, 1, and 5 weeks after transplantation, and the livers were prepared for microscopic examination.
RESULTS: Cellular necrosis, bridging necrosis, congestion in the hepatic sinusoid, and inflammatory cell infiltration were seen in the chemically injured livers 6 h after model establishment, and these changes were ameliorated in rats receiving BMSC transplantation.
CONCLUSIONS: Allogeneic BMSC transplantation can repair chemically induced acute liver injuries.