Journal of clinical psychopharmacology · 2014
Lactulose-associated lithium toxicity: a case series.
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Bregman Andrew, Fritz Kathy, Xiong Glen L
Аннотация
BACKGROUND: Lactulose is commonly used for constipation and hepatic encephalopathy. Its adverse effects of dehydration and serum electrolyte imbalances are widely known.
OBJECTIVE: This study aimed to describe a case series of 3 patients receiving lactulose who developed lithium toxicity.
METHODS: The authors described a case series of 3 patients admitted to a large county psychiatric hospital who developed lithium toxicity while taking lactulose for constipation or hyperammonemia.
RESULTS: In all 3 cases of lithium toxicity, the patients were prescribed with lithium for acute mania and lactulose for constipation or hyperammonemia. One case required the patient to be transferred to a local emergency department for further treatment.
CONCLUSIONS: This case series shows the interaction between lithium and lactulose. It is postulated that lactulose's effects of volume depletion can lead to poor renal excretion of lithium.
OBJECTIVE: This study aimed to describe a case series of 3 patients receiving lactulose who developed lithium toxicity.
METHODS: The authors described a case series of 3 patients admitted to a large county psychiatric hospital who developed lithium toxicity while taking lactulose for constipation or hyperammonemia.
RESULTS: In all 3 cases of lithium toxicity, the patients were prescribed with lithium for acute mania and lactulose for constipation or hyperammonemia. One case required the patient to be transferred to a local emergency department for further treatment.
CONCLUSIONS: This case series shows the interaction between lithium and lactulose. It is postulated that lactulose's effects of volume depletion can lead to poor renal excretion of lithium.