Where do you live? North versus Central-South differences in relation to Italian patients with oral lichen planus: a cross-sectional study from the SIPMO (Italian Society of Oral Pathology and Medicine).
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Adamo Daniela, Calabria Elena, Canfora Federica, Coppola Noemi, Lo Muzio Lorenzo, Spirito Francesca, Giuliani Michele, Azzi Lorenzo, Maurino Vittorio, Colella Giuseppe, Colella Chiara, Montebugnoli Lucio, Gissi Davide Bartolomeo, Gabriele Mario, Nisi Marco, Sardella Andrea, Lodi Giovanni, Varoni Elena Maria, Giudice Amerigo, Antonelli Alessandro, Arduino Paolo Giacomo, Gambino Alessio, Vescovi Paolo, Majorana Alessandra, Bardellini Elena, Campisi Giuseppina, Panzarella Vera, Spadari Francesco, Garagiola Umberto, Pentenero Monica, Sutera Samuele, Biasotto Matteo, Ottaviani Giulia, Gobbo Margherita, Guarda Nardini Luca, Romeo Umberto, Tenore Gianluca, Serpico Rosario, Lucchese Alberta, Lajolo Carlo, Rupe Cosimo, Aria Massimo, D'Aniello Luca, Mignogna Michele Davide, SIPMO (Italian Society of Oral Pathology and Medicine)
Аннотация
METHODS: 270 K-OLP and 270 nK-OLP patients were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS) were administered.
RESULTS: The Central-South K-OLP (CS-K-OLP) patients reported a higher frequency of pain/burning compared with the K-OLP patients of the North (N-K-OLP) with higher scores in the NRS and T-PRI (p value < 0.001**). The CS-K-OLP and the CS-nK-OLP patients showed higher scores in the HAM-D, HAM-A, PSQI and ESS compared with the Northern patients (p value < 0.001**). Multivariate logistic regression revealed that the NRS and T-PRI showed the greatest increase in the R2 value for the CS-K-OLP (DR2 = 9.6%; p value < 0.001**; DR2 = 9.7% p value < 0.001**; respectively) and that the oral symptoms (globus, itching and intraoral foreign body sensation) and PSQI showed the greatest increase in the R2 value for the CS-nK-OLP (DR2 = 5.6%; p value < 0.001**; DR2 = 4.5% p value < 0.001** respectively).
CONCLUSIONS: Pain and mood disorders are predominant in patients with OLP in the Central-South of Italy. Clinicians should consider that the geographical living area may explain the differences in oral symptoms and psychological profile in OLP.