Медицинская библиотека · Transplantation proceedings · 2006

Successful treatment of CCL4-induced acute liver failure with portal vein arterialization in the rat.

Nardo B, Puviani L, Caraceni P, Pacilè V, Bertelli R, Beltempo P, Cavallari G, Chieco P, Pariali M, Pertosa A M, Angiolini G, Domenicali M, Neri F, Tsivian M, Bernardi M, Cavallari A

СтатьяПеревод в очереди

Аннотация

INTRODUCTION

Optimization of the conditions for regeneration of the native diseased liver is a major goal in patients with acute liver failure. This study sought to determine whether portal vein arterialization (PVA), which increases the oxygen supply to the liver, was protective in a rat model of liver failure.

METHODS

At 24 hours after CCl(4) intoxication, Sprague-Dawley rats (six per group) were assigned to receive PVA or as controls. We determined blood tests, histology, and 10-day survivals. Hepatocyte regeneration was assessed by the mitotic index and bromodeoxyuridine (BrdU) incorporation.

RESULTS

Serum transaminases were significantly lower in PVA-treated rats than in control animals: liver necrosis resolved rapidly after PVA. The BrdU staining and mitotic index were severalfold higher among PVA-treated than in untreated rats. Survival was 100% among rats with PVA and 40% in untreated animals (P < .01).

CONCLUSIONS

PVA led to resolution of CCl(4)-induced massive liver necrosis in the rat. This effect was probably mediated by activation of rapid and extensive hepatocyte regeneration. PVA might provide a novel, alternative approach to treat acute liver failure.

Для цитирования: Nardo B, Puviani L, Caraceni P, Pacilè V, Bertelli R, Beltempo P, Cavallari G, Chieco P, Pariali M, Pertosa A M, Angiolini G, Domenicali M, Neri F, Tsivian M, Bernardi M, Cavallari A. Successful treatment of CCL4-induced acute liver failure with portal vein arterialization in the rat.. Transplantation proceedings. 2006. DOI: 10.1016/j.transproceed.2006.03.056.

Предметные рубрики MeSH

Alanine Transaminase Animals Aspartate Aminotransferases Carbon Tetrachloride Poisoning Disease Models, Animal Liver Circulation Liver Failure Liver Function Tests Male Portal Vein Prothrombin Time Rats Rats, Sprague-Dawley

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.