Nature microbiology · 2016
Genomic diversity of EPEC associated with clinical presentations of differing severity.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Hazen Tracy H, Donnenberg Michael S, Panchalingam Sandra, Antonio Martin, Hossain Anowar, Mandomando Inacio, Ochieng John Benjamin, Ramamurthy Thandavarayan, Tamboura Boubou, Qureshi Shahida, Quadri Farheen, Zaidi Anita, Kotloff Karen L, Levine Myron M, Barry Eileen M, Kaper James B, Rasko David A, Nataro James P
Аннотация
Enteropathogenic Escherichia coli (EPEC) are diarrhoeagenic E. coli, and are a significant cause of gastrointestinal illness among young children in developing countries. Typical EPEC are identified by the presence of the bundle-forming pilus encoded by a virulence plasmid, which has been linked to an increased severity of illness, while atypical EPEC lack this feature. Comparative genomics of 70 total EPEC from lethal (LI), non-lethal symptomatic (NSI) or asymptomatic (AI) cases of diarrhoeal illness in children enrolled in the Global Enteric Multicenter Study was used to investigate the genomic differences in EPEC isolates obtained from individuals with various clinical outcomes. A comparison of the genomes of isolates from different clinical outcomes identified genes that were significantly more prevalent in EPEC isolates of symptomatic and lethal outcomes than in EPEC isolates of asymptomatic outcomes. These EPEC isolates exhibited previously unappreciated phylogenomic diversity and combinations of virulence factors. These comparative results highlight the diversity of the pathogen, as well as the complexity of the EPEC virulence factor repertoire.