Science (New York, N.Y.) · 2008
Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hildner Kai, Edelson Brian T, Purtha Whitney E, Diamond Mark, Matsushita Hirokazu, Kohyama Masako, Calderon Boris, Schraml Barbara U, Unanue Emil R, Diamond Michael S, Schreiber Robert D, Murphy Theresa L, Murphy Kenneth M
Аннотация
Although in vitro observations suggest that cross-presentation of antigens is mediated primarily by CD8alpha+ dendritic cells, in vivo analysis has been hampered by the lack of systems that selectively eliminate this cell lineage. We show that deletion of the transcription factor Batf3 ablated development of CD8alpha+ dendritic cells, allowing us to examine their role in immunity in vivo. Dendritic cells from Batf3-/- mice were defective in cross-presentation, and Batf3-/- mice lacked virus-specific CD8+ T cell responses to West Nile virus. Importantly, rejection of highly immunogenic syngeneic tumors was impaired in Batf3-/- mice. These results suggest an important role for CD8alpha+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection.
Предметные рубрики MeSH
Adoptive TransferAnimalsAntibodies, ViralBasic-Leucine Zipper Transcription FactorsCD4-Positive T-LymphocytesCD8 AntigensCross-PrimingCytotoxicity, ImmunologicDendritic CellsFemaleFibrosarcomaLymphocyte ActivationMaleMiceMice, Inbred C57BLRepressor ProteinsSpleenT-Lymphocytes, CytotoxicWest Nile FeverWest Nile virus