[Immunological status of people inoculated with various types of inactivated vaccine against tick-borne encephalitis].

As compared with cellular immunity tests, serological tests more frequently detect virus-specific immune response in humans immunized with concentrated purified vaccine (CV) against tick-borne encephalitis. Combined determination of cell reactions and antibody production after a single injection of the vaccine increases the rate of detection of specifically responding persons. The duration of the inactivated vaccine-induced immunity is determined not only by the level of serum antibodies but also by the state of immunological memory detectable by the capacity of the host to produce antibodies after another injection of the specific antigen. At 14 and 30 days after a single immunization with CV IgG antibody is found in the blood of the vaccinees. In the course of 3 vaccinations, the concentration of serum immunoglobulins, chemotaxic activity of leukocytes, and blood lymphocyte reactivity to mitogens do not change. The role of some immunological values as criteria for the evaluation of the effectiveness of vaccine purification from impurities is discussed.