Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi · 2014
Spectrophotometric method for estimation of bisoprolol fumarate in tablets.
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Panainte Alina Diana, Bibire Nela, Tântaru Gladiola, Apostu M, Vieriu Mădălina, Dorneanu V
Аннотация
UNLABELLED: Bisoprolol fumarate is prescribed for the treatment of hypertension and angina pectoris.
AIM: The purpose of this study was to develop a simple, sensitive, accurate, and reproducible method for estimation of bisoprolol fumarate in tablets.
MATERIAL AND METHODS: The proposed method was based on a yellow colored complex formed with tropaeolin 00, extractable in dichloromethane with maximum absorbance at 412 nm. The method was validated statistically.
RESULTS: The linearity domain was observed in the concentration of 5-30 microg/ml. The recovery studies confirmed the accuracy of the proposed method.
CONCLUSIONS: The proposed method can be applied for the routine analysis of bisoprolol from formulations.
AIM: The purpose of this study was to develop a simple, sensitive, accurate, and reproducible method for estimation of bisoprolol fumarate in tablets.
MATERIAL AND METHODS: The proposed method was based on a yellow colored complex formed with tropaeolin 00, extractable in dichloromethane with maximum absorbance at 412 nm. The method was validated statistically.
RESULTS: The linearity domain was observed in the concentration of 5-30 microg/ml. The recovery studies confirmed the accuracy of the proposed method.
CONCLUSIONS: The proposed method can be applied for the routine analysis of bisoprolol from formulations.